AllergoBon

Allergen immunotherapy is the only cure for allergies. Oral allergen immunotherapy is comfortable as the allergen can be dropped or sprayed into the mouth by the patient him/herself.  

To further improve the safety and efficacy of oral allergen immunotherapy, we entrap the allergen into biodegradable PLGA microspheres. The microparticles are further decorated with Alaurea aurantia lectin (AAL). AAL is derived from an edible mushroom and specifically directs the microparticles to immune checkpoints in the mouth and intestine. 

Figure:  Building of  AAL-PLGA-allergen microparticle.

 


Patent family

Antigen-containing microspheres for the treatment of allergies.
Inventors: Jensen-Jarolim Erika, Roth-Walter Franziska, Gabor Franz.
WO200500274, patented in Europe, US, Australia, Canada, Japan.

Scientific Publications

Biodegradable PLGA particles for improved systemic and mucosal treatment of Type I allergy. Schöll I, Kopp T, Bohle B, Jensen-Jarolim E. Immunol Allergy Clin North Am. 2006 May;26(2):349-64, ix. Review.

Targeting antigens to murine and human M-cells with Aleuria aurantia lectin-functionalized microparticles. Roth-Walter F, Bohle B, Schöll I, Untersmayr E, Scheiner O, Boltz-Nitulescu G, Gabor F, Brayden DJ, Jensen-Jarolim E. Immunol Lett. 2005 Sep 15;100(2):182-8.

Schöll I, Boltz-Nitulescu G, Jensen-Jarolim E. Review of novel particulate antigen delivery systems with special focus on treatment of type I allergy. J Control Release. 2005 May 5;104(1):1-27. Epub 2005 Mar 2. Review.

Mucosal targeting of allergen-loaded microspheres by Aleuria aurantia lectin. Roth-Walter F, Schöll I, Untersmayr E, Ellinger A, Boltz-Nitulescu G, Scheiner O, Gabor F, Jensen-Jarolim E. Vaccine. 2005 Apr 15;23(21):2703-10.

M cell targeting with Aleuria aurantia lectin as a novel approach for oral allergen immunotherapy. Roth-Walter F, Schöll I, Untersmayr E, Fuchs R, Boltz-Nitulescu G, Weissenböck A, Scheiner O, Gabor F, Jensen-Jarolim E. J Allergy Clin Immunol. 2004 Dec;114(6):1362-8.

Functionalisation of allergen-loaded microspheres with wheat germ agglutinin for targeting enterocytes. Walter F, Schöll I, Untersmayr E, Ellinger A, Boltz-Nitulescu G, Scheiner O, Gabor F, Jensen-Jarolim E. Biochem Biophys Res Commun. 2004 Mar 5;315(2):281-7.

Allergen-loaded biodegradable poly(D,L-lactic-co-glycolic) acid nanoparticles down-regulate an ongoing Th2 response in the BALB/c mouse model.Schöll I, Weissenböck A, Förster-Waldl E, Untersmayr E, Walter F, Willheim M, Boltz-Nitulescu G, Scheiner O, Gabor F, Jensen-Jarolim E. Clin Exp Allergy. 2004 Feb;34(2):315-21.