The safety of new vaccines is a great concern. In case of systemic allergic reactions - called anaphylactic shock - the body temperature significantly drops and also physical activity is impaired.
Safety data from preclinical mouse models have predictive value for later clinical studies. Biomed therefore engaged in the development of an automated biomedical device for monitoring small laboratory animals. The "Imaging cage" can be used in laboratories to monitor physical activity simultaneously with body temperature in small animals.
The beta-version of the Imaging Cage is developed in collaboration with the Austrian Institute of Technology, supported by FFG and by the aws - Austria Wirtschaftsservice.
Figure: Imaging and real pictures of 4 mice in cage. Red: hot body areas, blue: coldest.
Published Biomed Patent
EP 13 15 8620.8; US 14/204,570 - 2013-03-11. Non-invasive temperature and physical activity measurement of animals.
Inventors: Jensen-Jarolim Erika, Flaschberger I.
Anaphylaxis imaging: Non-invasive measurement of temperature and physical activity of small animals.
Manzano-Szalai K, Pali-Schöll I, Krishnamurthy D, Flaschberger I, Jensen-Jarolim E.
PLoS One. 2016 Mar 10;11(3):e0150819. doi: 10.1371/journal.pone.0150819. eCollection 2016.
Adeno-associated virus-like particles as new carriers for B-cell vaccines: testing immunogenicity and safety in BALB/c mice. Manzano-Szalai K1, Thell K, Willensdorfer A, Weghofer M, Pfanzagl B, Singer J, Ritter M, Stremnitzer C, Flaschberger I, Michaelis U, Jensen-Jarolim E.
Viral Immunol. 2014 Nov;27(9):438-48. doi: 10.1089/vim.2014.0059. Epub 2014 Sep 23.