Nourish your Immune cells

Targeted Micronutrition

Allergy is a chronic inflammatory disease, in which micronutrients are less absorbed from the intestine. Hence allergy is associated with deficiency of iron and other micronutrients especially in immune cells. Immune cells of allergics are therefore undernourished.

These deficiencies cannot simply be compensated by healthy diet or intake of supplements. There is a need to target micronutrients exactly to allergic immune cells.

The lipocalin beta-lactoglobulin derives from cows milk and occurs in protective dust aerosols from cattle farms. Like all lipocalins it has a pocket for micronutrients. In a process called “targeted micronutrition”, beta-Lactoglobulin brings micronutrients exactly to the immune cells, like a registered letter.



How to nourish immune cells.

The beta-lactoglobulin can via a specific receptor target micronutrients to immune cells. Thereby, it fuels their micronutrient stocks and restores their nutritional deficiencies. Then, immune cells recover their normal function towards immune resilience.

Intellectual property

EP20140150965, 2014-01-13; US201615111162, 2016-07-12; Method and means for diagnosing and treating allergy. Inventors: Franziska Roth-Walter, Erika Jensen-Jarolim, Cristina Gomez-Casado, Araceli Diaz Perales, Luis Fernandez Pacios, Josef Singer.

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Key Publications

Micronutritional supplementation with a holoBLG-based FSMP (food for special medical purposes)-lozenge alleviates allergic symptoms in BALB/c mice: Imitating the protective farm effect. Afify SM, Regner A, Pacios LF, Blokhuis BR, Redegeld FA, Pali-Schöll I, Bartosic T, Petje L-M, Hufnagl K, Guethoff S, Kramer M, Fiocchi A, Dvorak Z, Jensen-Jarolim E, Roth-Walter F. Clin. Exp. Allergy, 2022 Mar;52(3):426-441. doi: 10.1111/cea.14050.

Secretory protein beta-lactoglobulin cattle stable dust may contribute to the allergy protective farm effect. Pali-Schöll I, Bianchini R, Hofstetter G, Winkler S, Ahlers S, Uhlenberg T, Afify SM, Hufnagl K, Hann S, Wittek T, Kasper-Giebl A, Pacios LF, Roth-Walter F, Vercelli D, von Mutius E, Jensen-Jarolim E. Clin Transl Allergy. 2022 Feb 12;12(2):e12125. doi: 10.1002/clt2.12125. eCollection 2022 Feb.

Bovine Holo-Beta-Lactoglobulin Cross-Protects Against Pollen Allergies in an Innate Manner in BALB/c Mice: Potential Model for the Farm Effect. Afify SM, Pali-Schöll I, Hufnagl K, Hofstetter G, El-Bassuoni MAR, Roth-Walter F, Jensen-Jarolim E. Frontiers in Immunology 2021 Mar 5;12:611474. doi: 10.3389/fimmu.2021.611474. eCollection 2021.

Functional iron-deficiency in allergic rhinitis patients correlate with symptom severity and microbial communities not relying on iron. Petje L-M*, Jensen SA*, Szikora S, Sulzbacher M, Bartosic T, Pjevac P, Hufnagl K, Loy A, Vyscocil E, Eckl-Dorner J, Jensen-Jarolim E, Hofstetter G, Afify SM, Krenn CG, Roth GA, Einwallner E, Hann S, Roth-Walter F. Allergy 2021, Sep;76(9):2882-2886. doi: 10.1111/all.14960. Epub 2021 Jun 17.

Cow’s milk protein β-lactoglobulin confers resilience against allergy by targeting complexed iron into immune cells. Roth-Walter F, Afify SM, Regner A, Vidovic A, Pali-Schöll I, Pacios LF, Dvorak Z, Hann S, Jensen-Jarolim E. JACI 2020, May 30:S0091-6749(20)30742-9. doi: 10.1016/j.jaci.2020.05.023.

Retinoic acid prevents immunogenicity of milk lipocalin Bos d 5 through binding to its immunodominant T-cell epitope. Hufnagl K, Ghosh D, Wagner S, Fiocchi A, Dahdah L, Bianchini R, Braun N, Steinborn R, Hofer M, Blaschitz M, Roth GA, Hofstetter G, Roth-Walter F, Pacios LF, Jensen-Jarolim E. SREP, 2018, 8 Jan 25;8(1):1598. doi: 10.1038/s41598-018-19883-0.

The major cow milk allergen Bos d 5 manipulates T-helper cells depending on its load with siderophore-bound iron. Roth-Walter F, Pacios LF, Gomez-Casado C, Hofstetter G, Roth GA, Singer J, Diaz-Perales A, Jensen-Jarolim E. PLOS one, August 12, 2014, doi: 10.1371/journal.pone.0104803.